WebAllovalency revisited: an analysis of multisite phosphorylation and substrate rebinding Jason W. Locasale1,* 1Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139. *[email protected] WebMar 21, 2008 · Allovalency revisited: an analysis of multisite phosphorylation and substrate rebinding. Journal Article (Journal Article) The utilization of multiple phosphorylation sites in regulating a biological response is ubiquitous in cell signaling. If each site contributes an additional, equivalent binding site, then one consequence of an increase in ...

Allovalency observed by transferred NOE: interactions of …

Ultrasensitivity can be achieved through several mechanisms: 1. Multistep mechanisms (examples: cooperativity) and multisite phosphorylation 2. Buffering mechanisms (examples: decoy phosphorylation sites) or stoichiometric inhibitors 3. Changes in localisation (such as translocation across the nuclear envelope) WebNov 11, 2003 · Allovalency: a case of molecular entanglement. Allovalency: a case of molecular entanglement. Allovalency: a case of molecular entanglement Curr Biol. 2003 … malissa wood cardiologist

Behaviour of intrinsically disordered proteins in protein–protein ...

WebFigure 1. The allovalency model. The proposed ultrasensitivity mechanism relies on describing a disordered protein, such as Sic1, as a random coil undergoing rapid gyrations within a molecular radius. The model proposed approximates such a random coil with a ‘cloud’ of rapidly diffusing binding sites (blue segments) capable of binding an WebNov 30, 2003 · Allovalency: A Case of Molecular Entanglement December 2003 Authors: Andre Levchenko Request full-text Abstract A large fraction of the total set of proteins in … WebAug 19, 2024 · Allovalency is defined as the presence of multiple, identical determinants arranged in tandem on an intrinsically disordered polypeptide that compete for binding to a receptor-binding site that can accommodate only one … mal is sick