Shythdf2
We analyzed The Cancer Genome Atlas (TCGA) and CHOICE datasets of Chinese patients with NSCLC to evaluate the expression profiles of m6A “write”, “eraser”, and “reader” genes (WERs) in LUAD23. The results showed that in both datasets, the mRNA expression levels of METTL3, VIRMA, RBM15, RBM15B, … See more Next, we investigated the effect of YTHDF2 on the aggressive capacities of LUAD in vitro. Our results showed that the ectopic overexpression of YTHDF2 in A549 … See more Given that YTHDF2 promotes mRNA degradation by targeting m6A-modified mRNAs to processing bodies in the cytoplasm, identifying the key factor that … See more WebApr 3, 2024 · A RPMI-8226 cells transfected with shNC or shYTHDF2 were injected in the left or right flanks of BALB/c nude mice (n = 4). B Mice were sacrificed when tumor diameter …
Shythdf2
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WebJan 11, 2024 · The lentiviral system was used to package YTHDF2 or shYTHDF2 lentiviral particles, and then virally infect the gastric cancer cell lines. The finally established … WebWe would like to show you a description here but the site won’t allow us.
WebJun 21, 2024 · Author summary Epstein–Barr virus (EBV) is a ubiquitous oncogenic virus that contributes to approximately 2% of all cancers by modulating a myriad of host cell activities. M6A is the most abundant RNA modification which is important for infection with HIV-1, HCV, Zika virus, KSHV and SV40 virus. The role of m6A modification and the … WebFeb 1, 2024 · On one hand, as shown in Fig. S4, neither cell proliferation nor colony-formation was affected when YTHDF2 was either knockdown or knockout by either two …
WebOct 29, 2024 · The whole metastatic model was established and detected using an in vivo imaging system after injecting PC-3 shYTHDF2 and shNC cells into tail vein of nude mice. … WebYTHDF2, also named as YTH domain-containing family protein 2, is a 579 amino acid protein, which contains 1 YTH domain. YTHDF2 specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a …
WebMar 10, 2024 · Dysregulation of long noncoding RNA (LncRNA) FENDDR has been shown to be closely related to the progression of several cancers. However, its role and upstream regulatory mechanism in endometrioid endometrial carcinoma (EEC) remains unclear.
phone with projector 2022WebJan 8, 2024 · shYTHDF2#1-resistant YTHDF2 to the YTHDF2-depleted GSCs rescued the malignant phenotypes of GSCs (Fig. 2 d – h, Supple- mentary Fig. 2h-k), suggesting that … how do you spell pennantWebNov 23, 2024 · Moreover, shYTHDF2 markedly triggered cell apoptosis and dysregulation of apoptotic proteins (Fig.2C). On the contrary, YTHDF2 overexpression resulted in reduced … how do you spell pentWebFeb 15, 2024 · 该研究揭示SUMO化修饰是m6A修饰阅读蛋白YTHDF2功能调控的一个新分子机制，并阐明了其在肿瘤发生中的重要作用。. RNA是遗传信息从DNA传递到蛋白质的关 … how do you spell pennywiseWebNov 23, 2024 · Abstract. N 6-methyladenosine (m 6 A) is a reversible modification in mRNA and has been shown to regulate processing, translation and decay of mRNA. However, the roles of m 6 A modification in neuronal development are still not known. Here, we found that the m 6 A eraser FTO is enriched in axons and can be locally translated. Axon-specific … how do you spell penitWebFeb 12, 2024 · Four stable H1299 cell lines (control, sh-YTHDF2, shYTHDF2-WT and shYTHDF2-K 571 R) were injected into the flanks of nude mice subcutaneously. Being … how do you spell pensionWebMar 10, 2024 · Dysregulation of long noncoding RNA (LncRNA) FENDDR has been shown to be closely related to the progression of several cancers. However, its role and upstream … phone with qwerty keyboard 2017