WebJan 15, 2002 · Biosynthesis of Peptide Antibiotics. K. Kurahashi. Biology, Chemistry. 1981. TLDR. The author considers that it describes best the novel type of peptide biosynthesis and proposes to term it the ‘multienzyme thiotemplate mechanism’. 11. WebAbstract. Several species of the genus Bacillus produce peptide antibiotics which are synthesized either through a ribosomal or non-ribosomal mechanism. The antibiotics …
Thiotemplate mechanism - Oxford Reference
WebJan 5, 2024 · Nonribosomal peptide synthetases (NRPSs) are modular enzymes that use a thiotemplate mechanism to assemble the peptide backbones of structurally diverse and … WebThe lipopeptide antibiotic surfactin was first isolated as a fibrin clotting inhibitor from Bacillus subtilis ATCC21332 133 is one of the most significant biosurfactants known today. 10 Although it is synthesized nonribosomally in part, by the multienzyme thiotemplate mechanism 24 at stationary phase, 134 this species also adopts a different ... folded graduation announcements
Mechanism of cyclosporin A biosynthesis. Evidence for synthesis …
WebAug 6, 2015 · The synthesis proceeds by a thiotemplate mechanism whereby intermediates are covalently attached to the PKS. The release of the final polyketide is catalyzed by the … WebThiotemplate NRPs – Lipopeptides Lipopeptides are usually synthetized through a NRPS sequential addition of AA residues, either in an iterative or non-iterative way. Similarly to … WebFeb 1, 1991 · The amino acid sequences of the genes coding for four multienzyme peptide synthetases, operating by the thiotemplate mechanism are compared, to show underlying principles in the biosynthetic ... folded graduation announcements 2022