Triacetin genotoxicity
WebAug 31, 2024 · Pfuhler S et al., 2009 Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities—Report from an ECVAM workshop Mutation Research 680 (2009) 31-42. Dertinger SD (2010) Integration of Mutation and Chromosomal Damage Endpoints into 28-Day Repeat Dose Toxicology Studies. WebTriacetine (Triacetin) = Glyceryl triacetate = Glycerol triacetate = Glycerin triacetate. CAS number: 102-76-1 EC number: 203-051-9 Molecular formula: C9H14O6. Triacetine (Triacetin) is a triglyceride obtained by acetylation of the three hydroxy groups of glycerol.
Triacetin genotoxicity
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WebTRIACETIN. Triacetin is a triglyceride obtained by acetylation of the three hydroxy groups of glycerol. Triacetin has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections. Triacetin has a role as a plant metabolite, a solvent, a fuel additive, an adjuvant, a food ... WebGENOTOXICITY: SPECIFIC ASPECTS OF REGULATORY GENO-TOXICITY TESTS FOR PHARMACEUTICALS ICH Harmonised Tripartite Guideline TABLE OF CONTENTS 1. INTRODUCTION 3 2. SPECIFIC GUIDANCE AND RECOMMENDATIONS 3 2.1 Specific guidance for in vitro tests 3 2.1.1 The base set of strains used in bacterial mutation …
Triacetin, is the organic compound with the formula C3H5(OCOCH3)3. It is classified as a triglyceride, i.e., the triester of glycerol. It is a colorless, viscous, and odorless liquid with a high boiling point and a low melting point. It has a mild, sweet taste in concentrations lower than 500 ppm, but may appear bitter at higher concentrations. It is one of the glycerine acetate compounds. WebTriacetin C9H14O6 CID 5541 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity …
WebMay 22, 2024 · Genotoxicity refers to the ability of harmful substances to damage genetic information in cells. Being exposed to chemical and biological agents can result in genomic instabilities and/or epigenetic alterations, which translate into a variety of diseases, cancer included. This concise review discusses, from both a genetic and epigenetic point of view, … WebJul 5, 2024 · In this study, the cytotoxicity and genotoxicity caused by triacetin (E15 18) in the mit otic cycle of . Allium cepa. root tips (2n= 16) were established. Firstly, the EC 50 …
WebIntroduction. Triacetin is a triester of glycerin and acetic acid. It has been used for over 75 years for a wide range of uses, including cosmetic biocide (most often as a fungicide), …
WebSimilar term(s): genotoxicity. Definition: Toxic (damaging) to DNA. Substances that are genotoxic may bind directly to DNA or act indirectly leading to DNA damage by affecting enzymes involved in DNA replication, thereby causing mutations which may or may not lead to cancer or birth defects (inheritable damage). Genotoxic ... chelmsford tips todayWebTriacetin into the corium of human skin was determined by top-ical application of Triacetin to the epidermis (which was later separated from the corium), and then measuring the … chelmsford tk maxxWebgenotoxicity; carcinogenicity; reproductive and developmental toxicity. ISO 10993-3:2014 is applicable when the need to evaluate a medical device for potential genotoxicity, carcinogenicity, or reproductive toxicity has been established. General information . Status : Published. Publication date : 2014-10. chelmsford tip opening times